4-Nitrophenyl chloroformate → 4-Nitrophenyl 2-(3-thiophenyl)ethyl carbonate

HRID 36483

반응식

HRID 36483 반응식
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][CH2:7][OH:8])=[CH:2]1.Cl[C:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][CH:14]=1)=[O:11]>>[C:10](=[O:11])([O:8][CH2:7][CH2:6][C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)[O:12][C:13]1[CH:14]=[CH:15][C:16]([N+:19]([O-:21])=[O:20])=[CH:17][CH:18]=1

참가 물질

3

반응물 2

HCID 821294-Nitrophenyl chloroformateHCID 83731Thiophene-3-ethanol

생성물 1

HCID 570943314-Nitrophenyl 2-(3-thiophenyl)ethyl carbonate

실험 절차

Using the method of Example 7a, 3-thiopheneethanol was treated with 4-nitrophenyl chloroformate to afford, after purification by flash chromatography (EtOAc:hexane (1:9)), the title product (56%); TLC, Rf =0.25, EtOAc:hexane (1:9).

후처리

  1. customto afford
  2. customafter purification by flash chromatography (EtOAc:hexane (1:9))

출처 및 근거

ORD 기록
ord-5c4202d739af496d99d2ebc2c9abeb12
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05414132

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