Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propionate ion → 3-(2-Nitrophenyl)isoxazolin-5-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propionate ion | HCID 104745 | — |
| 반응물 | Butyrate | HCID 104775 | — |
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | Ethyl 2-nitro-beta-oxobenzenepropanoate | HCID 10561837 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(2-Nitrophenyl)isoxazolin-5-one | HCID 21271853 | — |
반응 단계
The reactions of Equations 15a and 15b above can be run by procedures similar to those described in U.S. Pat. No. 3,781,438 for the preparation of 5-halo-3-phenylisoxazoles. Thus, in reaction 15a, an ethyl 2-(2-nitrobenzoyl)acetate, propionate or butyrate of Formula (XIV) is reacted with hydroxylamine hydrochloride and sodium acetate in ethanol at reflux for 0.5 to 5 hours to form a 3-(2-nitrophenyl)isoxazolin-5-one of Formula (XXVI). In reaction 15b, XXVI is reacted with an equimolar amount of triethylamine and excess phosphorus oxychloride or phosphorus oxybromide in toluene at 25° to 110° C. for 1 to 5 hours to form Xc"'.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04606755 |
| 출처 데이터셋 | uspto-grants-1986_08 |
| ORD ID | ord-cb8e304acedb42a3ba4e8998b434a0dc |
| 출처 메모 | uspto-grants-1986_08 |