Ethanol → Ethyl 4-formylbenzoate

HRID 36488

반응식

HRID 36488 반응식
[CH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1)=[O:2].[CH3:12][CH2:13]O.CCOCC>ClCCCl>[CH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([O:9][CH2:12][CH3:13])=[O:8])=[CH:5][CH:4]=1)=[O:2]

참가 물질

5

반응물 3

HCID 702EthanolHCID 3283Diethyl EtherHCID 120884-Formylbenzoic acid

생성물 1

HCID 80498Ethyl 4-formylbenzoate수율 68%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

A mixture of 4-formylbenzoic acid (25 g) conc sulfuric acid (2 ml) and EtOH (19.5 ml) was refluxed gently for 5 days in 100 ml of 1,2-dichloroethane. The solvent was then stripped, and Et2O was added to the residue. The Et2O solution was washed (satd aq NaHCO3) dried (Na2SO4), filtered, and evaporated. Bulb to bulb distillation afforded 20.1 g (68%) of the title ester as a clear liquid, bp 145°-150° (2,900 Pascals, 22 torr).

후처리

  1. washThe Et2O solution was washed (satd aq NaHCO3)
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. customevaporated
  5. distillationBulb to bulb distillation

출처 및 근거

ORD 기록
ord-04e21b8f0b284580b11a384d44c8297e
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05414132

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