Chlorosulfonic acid → 3-Methoxy-5,6,7,8-tetrahydronaphthalene-2-sulfonyl chloride

HRID 364895

반응식

HRID 364895 반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=1.[Cl:13][S:14](O)(=[O:16])=[O:15]>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:12]([S:14]([Cl:13])(=[O:16])=[O:15])=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=1

참가 물질

4

반응물 2

HCID 24638Chlorosulfonic acidHCID 744146-Methoxytetralin

생성물 1

HCID 132103423-Methoxy-5,6,7,8-tetrahydronaphthalene-2-sulfonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
5 °C

실험 절차

118 g (0.73 mole) of 5,6,7,8-tetrahydro-2-naphthol methyl ether are dissolved in 320 ml of methylene chloride, and 177 ml of chlorosulfonic acid in 160 ml of methylene chloride are added. The mixture is stirred for 10 minutes at 5° C. and is poured into ice water. The organic phase is separated off and dried with MgSO4. The solvent is removed by evaporation and the residue is recrystallized from acetone/petroleum ether.

후처리

  1. customThe organic phase is separated off
  2. dry with materialdried with MgSO4
  3. customThe solvent is removed by evaporation
  4. customthe residue is recrystallized from acetone/petroleum ether

출처 및 근거

ORD 기록
ord-9bacb43ee4cb43199d5ffc4dd58e4573
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04607030

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