Pyridine → N-[(5-tert-Butyl-2-hydroxyphenyl)methyl]acetamide

HRID 364896노트

반응식

HRID 364896 반응식
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:6][C:5]=1[OH:14].N1C=CC=CC=1.[C:21](Cl)(=[O:23])[CH3:22]>O1CCOCC1>[C:21]([NH:2][CH2:3][C:4]1[CH:9]=[C:8]([C:10]([CH3:11])([CH3:13])[CH3:12])[CH:7]=[CH:6][C:5]=1[OH:14])(=[O:23])[CH3:22]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 212969502-(Aminomethyl)-4-tert-butylphenol hydrochloride

생성물 1

HCID 13210348N-[(5-tert-Butyl-2-hydroxyphenyl)methyl]acetamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

43 g (0.2 mole) of 2-aminomethyl-4-(1,1-dimethylethyl)-phenol hydrochloride are suspended in 400 ml of 1,4-dioxane, and 40 ml of pyridine are added. 40 ml (0.55 mole) of acetyl chloride are added dropwise while stirring and cooling with ice. The mixture is then stirred for 2.5 hours at 90° and poured into ice water, and the precipitate which has crystallized out is filtered off with suction.

후처리

  1. temperaturecooling with ice
  2. stirringThe mixture is then stirred for 2.5 hours at 90°
  3. customthe precipitate which has crystallized out
  4. filtrationis filtered off with suction

출처 및 근거

ORD 기록
ord-dcd443eda4674388a7bbb90b3deda725
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04607030

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