Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 2-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 5-Indanol | HCID 15118 | — |
| 반응물 | N-Methylol-alpha-chloroacetamide | HCID 62466 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide | HCID 21296915 | — |
반응 단계
134 g (1 mole) of 5-hydroxyindane and 100 g (0.81 mole) of 2-chloro-N-hydroxymethylacetamide are suspended in 300 ml of glacial acetic acid, and 10 ml of concentrated sulfuric acid are added. The mixture is stirred for 30 minutes at room temperature and is poured into ice water. The product is filtered off with suction and recrystallized from methanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04607030 |
| 출처 데이터셋 | uspto-grants-1986_08 |
| ORD ID | ord-ecaa98b7278c4f35a2279ce3ff24fee3 |
| 출처 메모 | uspto-grants-1986_08 |