Chlorosulfonic acid → 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

HRID 364909

반응식

HRID 364909 반응식
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[CH:9][C:8]=1[OH:16])=[O:4].[Cl:17][S:18](O)(=[O:20])=[O:19]>>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:18]([Cl:17])(=[O:20])=[O:19])[C:8]=1[OH:16])=[O:4]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 212969152-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide

생성물 1

HCID 212969316-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

실험 절차

70 g (0.29 mole) of 6-(N-chloroacetylaminomethyl)-5-hydroxyindane are dissolved in 150 ml of chlorosulfonic acid, and the mixture is stirred for approx. 30 minutes at room temperature. The mixture is poured into ice water and the product is filtered off with suction. The initially crystalline material becomes oily after a little time and is employed in the next stage in this form without further purification.

후처리

  1. filtrationthe product is filtered off with suction
  2. customis employed in the next stage in this form without further purification

출처 및 근거

ORD 기록
ord-b261b528b5324d1898ca17168a21389b
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04607030

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