Phenylacetic Acid → Benzeneacetamide, N-(2-acetylphenyl)-

HRID 364925

반응식

HRID 364925 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].[C:11]1([CH2:17][C:18](O)=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:18](=[O:19])[CH2:17][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:10])[CH3:9]

참가 물질

5

반응물 3

HCID 999Phenylacetic AcidHCID 10868DicyclohexylcarbodiimideHCID 110862'-Aminoacetophenone

생성물 1

HCID 218938Benzeneacetamide, N-(2-acetylphenyl)-

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of o-aminoacetophenone (25 g.) and phenylacetic acid (25 g.) in anhydrous methylene dichloride (200 ml.) was prepared. To that mixture was added dicyclohexylcarbodiimide (40 g.) in portions of approx. 10 g. every 5 min. at ambient temperature. When the addition was completed the mixture was stirred for 4 hr. at ambient temperature. The mixture was then filtered, and the filtrate was evaporated in vacuo to dryness. The residue was crystallised from cyclohexane to give o-acetyl-N-(phenylacetyl)aniline, m.p. 78°.

후처리

  1. customwas prepared
  2. customevery 5 min.
  3. customat ambient temperature
  4. additionWhen the addition
  5. customat ambient temperature
  6. filtrationThe mixture was then filtered
  7. customthe filtrate was evaporated in vacuo to dryness
  8. customThe residue was crystallised from cyclohexane

출처 및 근거

ORD 기록
ord-c30de0092d444a9b9d4cc6dd5c8c2e66
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04607039

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