Piperidine → 2-[4-(Diethylamino)styryl]-1-hexylpyridinium bromide hemihydrate

HRID 365122

반응식

HRID 365122 반응식
[Br-:1].[CH2:2]([N+:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH3:14])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH2:15]([N:17]([CH2:26][CH3:27])[C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=1)[CH3:16].N1CCCCC1>CO>[OH2:23].[Br-:1].[CH2:26]([N:17]([CH2:15][CH3:16])[C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[CH:14][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][N+:8]=2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])=[CH:20][CH:19]=1)[CH3:27].[CH2:15]([N:17]([C:18]1[CH:19]=[CH:20][C:21]([CH:22]=[CH:14][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][N+:8]=2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])=[CH:24][CH:25]=1)[CH2:26][CH3:27])[CH3:16].[Br-:1]

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 671144-(Diethylamino)benzaldehydeHCID 219878661-Hexyl-2-methylpyridinium bromide

생성물 1

HCID 704553642-[4-(Diethylamino)styryl]-1-hexylpyridinium bromide hemihydrate수율 45.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-Hexyl-2-methylpyridinium bromide (7.8 g, 0.03 mole) and 4-diethylaminobenzaldehyde (7.0 g, 0.04 mole) were refluxed in methanol (50 ml) in the presence of piperidine (1.0 ml) under nitrogen for four hours. The solution was evaporated and the resulting oil was redissolved in a small amount of isopropanol. Addition of twice the volume of ether gave a red crystalline solid which was collected and washed with isopropanol/ether to give 2-[4-(diethylamino)styryl]-1-hexylpyridinium bromide hemihydrate (5.8 g), melting point 222°-223° (decomposition).

후처리

  1. customThe solution was evaporated
  2. dissolutionthe resulting oil was redissolved in a small amount of isopropanol
  3. additionAddition of twice the volume of ether
  4. customgave a red crystalline solid which
  5. customwas collected
  6. washwashed with isopropanol/ether

출처 및 근거

ORD 기록
ord-309cd08193b94334b1b909faff8e5a58
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04608379

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