2-Methylpyridine → 1-Hexyl-2-[(4-piperidino)styryl]-pyridinium bromide

HRID 365128노트

반응식

HRID 365128 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:7].[Br:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[N:15]1([C:21]2[CH:28]=[CH:27][C:24]([CH:25]=O)=[CH:23][CH:22]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.N1CCCCC1>CO.CCOCC>[Br-:8].[CH2:9]([N+:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[CH:25][C:24]1[CH:23]=[CH:22][C:21]([N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:28][CH:27]=1)[CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

참가 물질

7

반응물 4

HCID 79752-MethylpyridineHCID 8082PiperidineHCID 81011-BromohexaneHCID 2913544-(Piperidin-1-yl)benzaldehyde

생성물 1

HCID 704551961-Hexyl-2-[(4-piperidino)styryl]-pyridinium bromide수율 16.3%

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

2-Picoline (2.79 g, 0.03 mole) and 1-bromo-hexane (5.0 g, 0.03 mole) were heated in an oil bath at 130° C. for five hours. The resulting oil was cooled and dissolved in methanol (40 ml). 4-Piperidinobenzaldehyde (5.67 g, 0.03 mole) and piperidine (0.25 ml) were added and the mixture was refluxed under nitrogen for two hours. The addition of about 100 ml of ether to the cold solution gave red crystals which were collected and washed to give 1-hexyl-2-[(4-piperidino)styryl]-pyridinium bromide (2.1 g), melting point 212°-214° C. (decomposition).

후처리

  1. temperatureThe resulting oil was cooled
  2. temperaturethe mixture was refluxed under nitrogen for two hours
  3. customgave red crystals which
  4. customwere collected
  5. washwashed

출처 및 근거

ORD 기록
ord-d4ae4e84612e488d90a28cbe0a27cb90
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04608379

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