Potassium Carbonate → 11-{1-[3-(1,3-Dihydro-2-oxo-2H-benzimidazol-1-yl)propyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine oxalate

HRID 365135

반응식

HRID 365135 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:3][CH2:2]1.Cl[CH2:22][CH2:23][CH2:24][N:25]1[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[NH:27][C:26]1=[O:34].[C:35]([O-])([O-:37])=[O:36].[K+].[K+]>CN(C=O)C>[C:26]([OH:34])(=[O:8])[C:35]([OH:37])=[O:36].[O:34]=[C:26]1[N:25]([CH2:24][CH2:23][CH2:22][N:1]2[CH2:2][CH2:3][CH:4]([CH:7]3[C:13]4=[CH:14][CH:15]=[CH:16][N:12]4[CH2:11][C:10]4[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=4[O:8]3)[CH2:5][CH2:6]2)[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[NH:27]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 18104191-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-oneHCID 1368935811-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine

생성물 1

HCID 2019168511-{1-[3-(1,3-Dihydro-2-oxo-2H-benzimidazol-1-yl)propyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine oxalate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 50 ml dry DMF were added 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (5.0 g, 0.0186 mole), 1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one (4.0 g 0.019 mole), milled K2CO3 (10 g, 0.07 mole) and KI (0.01 g).

출처 및 근거

ORD 기록
ord-df8363d24d8d471fa045dddfeb28830f
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04608374

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