Dimethylformamide → 11-{1-[2-(Phenyl)ethyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine oxalate

참여 물질

역할	이름	HCID	투입량
반응물	Dimethylformamide	HCID 6228	—
반응물	Phenethyl bromide	HCID 7666	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	11-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine	HCID 13689358	—
생성물	11-{1-[2-(Phenyl)ethyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine oxalate	HCID 20191679	—

반응 조건

온도	90 °C

반응 단계

To 50 ml DMF were added 11-(piperidin-4-yl]-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (4.5 g, 0.017 mole), (2-bromoethyl)-benzene (4.3 ml, 0.03 mole), milled K2CO3 (10.0 g, 0.07 mole) and KI (0.01 g). After stirring at 90° C. for four hours the mixture was cooled and filtered, and the filtrate was concentrated in vacuo to an oil. This oil was dissolved in ethyl acetate, washed twice with water and dried (saturated NaCl, anhydrous MgSO4).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US04608374
출처 데이터셋	uspto-grants-1986_08
ORD ID	ord-4a0197bcf38041eaa9c2b2fbe18c0959
출처 메모	uspto-grants-1986_08