Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 365155생성일: 2026년 10월 26일
Potassium Carbonate → 11-{1-[2-(4-Trifluoromethylphenyl)ethyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine
https://huagongshe.com/reaction/365155
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 11-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689358 | — |
| 반응물 | 4-Trifluoromethylphenethyl methanesulfonate | HCID 54310915 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 11-{1-[2-(4-Trifluoromethylphenyl)ethyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689409 | — |
반응 단계
A mixture of 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (5.07 g, 0.019 mole), (p-trifluoromethylphenyl)ethyl methanesulfonate (6.08 g, 0.023 mole) and K2CO3 (10.7 g) in 150 ml dimethylformamide was heated at 90° C. for 7 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04608374 |
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| 출처 데이터셋 | uspto-grants-1986_08 |
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| ORD ID | ord-09bb66417c534cf6a71efd1348a43b4c |
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| 출처 메모 | uspto-grants-1986_08 |
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