Water → 2-Cyclopenten-1-one, 4-hydroxy-3-methyl-2-(2-propen-1-yl)-
반응식
C(O[C:5]1([CH3:14])[CH:9]=[CH:8][C:7](=[O:10])[CH:6]1[CH2:11][CH:12]=[CH2:13])(=O)C.[OH2:15]>C(O)(=O)C>[CH2:11]([C:6]1[C:7](=[O:10])[CH2:8][CH:9]([OH:15])[C:5]=1[CH3:14])[CH:12]=[CH2:13]참가 물질
4
실험 절차
In the same flask as in Example 1, there were charged 3-acetoxy-2-allyl-3-methyl-4-cyclopentenone (3.0 g), water (10 g) and acetic acid (5 g), and the resultant mixture was stirred under reflux for 10 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and extracted three times with methyl isobutyl ketone (60 ml). The organic layers were combined together, washed with water and dried over magnesium sulfate. After concentration under reduced pressure, the residue was purified by column chromatography to give 1.95 g of 2-allyl-4-hydroxy-3-methyl-2-cyclopentenone. Yield, 83%.
후처리
- temperatureunder reflux for 10 hours
- customAfter completion of the reaction
- concentrationthe reaction mixture was concentrated under reduced pressure
- extractionextracted three times with methyl isobutyl ketone (60 ml)
- washwashed with water
- dry with materialdried over magnesium sulfate
- concentrationAfter concentration under reduced pressure
- customthe residue was purified by column chromatography
출처 및 근거
- ORD 기록
- ord-c0a3c93f68014ee287ff1d653ba17c30
- 출처 데이터셋
- uspto-grants-1986_08
- 특허 번호
- US04608442
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