Phenyl glycidyl ether → 1-Phenoxy-3-[4-(1,3,5-trimethylpyrimidine-2,4-dion-6-ylamino)-butylamino]-propan-2-ol

HRID 365197노트

반응식

HRID 365197 반응식
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:2]1[O:4][CH2:3]1.[NH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[N:19]([CH3:28])[C:20](=[O:27])[N:21]([CH3:26])[C:22](=[O:25])[C:23]=1[CH3:24]>>[O:5]([CH2:1][CH:2]([OH:4])[CH2:3][NH:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][C:18]1[N:19]([CH3:28])[C:20](=[O:27])[N:21]([CH3:26])[C:22](=[O:25])[C:23]=1[CH3:24])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

3

반응물 2

HCID 31217Phenyl glycidyl etherHCID 202378604-(4-aminobutylamino)-1,3,5-trimethylpyrimidine-2,6(1H,3H)-dione

생성물 1

HCID 202377801-Phenoxy-3-[4-(1,3,5-trimethylpyrimidine-2,4-dion-6-ylamino)-butylamino]-propan-2-ol

실험 절차

4.5 g. Phenyl glycidyl ether and 12.0 g. 4-(4-aminobutylamino)-1,3,5-trimethylpyrimidine-2,6(1H,3H)-dione are mixed and left to stand for 48 hours at ambient temperature. The reaction mixture is then separated chromatographically and salt formation is carried out in the manner described in Example 29. There are obtained 2.6 g. (19% of theory) of the desired product in the form of colorless crystals; m.p. 148°-150° C., with bubble formation.

후처리

  1. waitleft
  2. customThe reaction mixture is then separated chromatographically
  3. customThere are obtained 2.6 g

출처 및 근거

ORD 기록
ord-b1b2c38b3b4d458f9706c518285cd4bf
출처 데이터셋
uspto-grants-1986_08
특허 번호
US04608383

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