N,N-Dimethyl-1,4-dioxaspiro[4.5]decan-8-amine → 4-(Dimethylamino)cyclohexan-1-one

HRID 365251노트

반응식

HRID 365251 반응식
C1O[C:4]2([CH2:9][CH2:8][CH:7]([N:10]([CH3:12])[CH3:11])[CH2:6][CH2:5]2)[O:3]C1>C(O)=O>[CH3:11][N:10]([CH3:12])[CH:7]1[CH2:8][CH2:9][C:4](=[O:3])[CH2:5][CH2:6]1

참가 물질

3

반응물 1

HCID 361167N,N-Dimethyl-1,4-dioxaspiro[4.5]decan-8-amine

생성물 1

HCID 103745454-(Dimethylamino)cyclohexan-1-one수율 100%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

4.96 gm (26.8 mMol) 4-dimethylamino-1-cyclohexanone ethylene ketal were dissolved in 50 mL formic acid and the solution stirred at reflux for 18 hours. The reaction mixture was then cooled to ambient and the volatiles removed under reduced pressure to give 3.78 gm (100%) of the title compound.

후처리

  1. temperatureat reflux for 18 hours
  2. temperatureThe reaction mixture was then cooled to ambient and the volatiles
  3. customremoved under reduced pressure

출처 및 근거

ORD 기록
ord-3e59ea4ef37c4843a7b851f41bcc0878
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06126932

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