Bis(2-chloroethyl)amine hydrochloride → Eltoprazine

HRID 365292노트

반응식

HRID 365292 반응식
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([NH2:11])[C:5]=2[O:4][CH2:3][CH2:2]1.Cl.Cl[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]Cl>ClC1C=CC=CC=1>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([N:11]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[C:5]=2[O:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 522769Bis(2-chloroethyl)amine hydrochlorideHCID 117883872,3-Dihydro-1,4-benzodioxin-5-amine

생성물 1

HCID 65853Eltoprazine수율 90.8%

시약·촉매·용매 1

HCID 7964Chlorobenzene용매

실험 절차

The solution of the product of example 13 (1.50 g, 0.010 mol) and bis(2-chloroethyl)amine hydrochloride (1.77 g 0.01 mol) in chlorobenzene (20 ml) was heated under reflux for 24 h, cooled to room temperature and evaporated in vacuo. The white solid was dissolved in aqueous sodium hydroxide (100 ml) and extracted into ethyl acetate (3×50 ml). The extracts were dried (MgSO4) and evaporated in vacuo to give the product (2.00 g).

후처리

  1. temperatureunder reflux for 24 h
  2. customevaporated in vacuo
  3. dissolutionThe white solid was dissolved in aqueous sodium hydroxide (100 ml)
  4. extractionextracted into ethyl acetate (3×50 ml)
  5. dry with materialThe extracts were dried (MgSO4)
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-c5756552bbd3491fba645fbf4c5e7481
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06127357

반응 노트

불러오는 중…