Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(4-(2-Methoxyphenyl)piperazin-1-yl)propanenitrile → 1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(4-(2-Methoxyphenyl)piperazin-1-yl)propanenitrile | HCID 1822604 | — |
| 촉매 | Rhodium | HCID 23948 | — |
| 용매 | Ammonia | HCID 222 | — |
| 생성물 | 1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine | HCID 10467259 | 86.9% |
반응 단계
A solution of the product of Example 26 (4.4 g, 18 mmol) in concentrated ethanolic ammonia solution (150 ml) was hydrogenated over 5% rhodium on alumina powder (0.6 g) at 50 p.s.i. (about 3.4×105Pa) for 50 h to give the product (3.9 g) as a brown oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06127357 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-b9864ad77a494dd3a63c53c478ce0381 |
| 출처 메모 | uspto-grants-2000_10 |