Trifluoroacetic acid → 5-(2-Chloroethyl)Oxindole

HRID 365368노트

반응식

HRID 365368 반응식
[Cl:1][CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)=O.FC(F)(F)C(O)=O.C([SiH](CC)CC)C>>[Cl:1][CH2:2][CH2:3][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2

참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 20605765-(Chloroacetyl)-1,3-dihydro-2H-indol-2-one

생성물 1

HCID 145813925-(2-Chloroethyl)Oxindole

실험 절차

To a 100 ml round-bottomed flask equipped with condenser and nitrogen inlet were added 5.0 grams (23.9 mmol) of 5-chloroacetyl oxindole and 18.5 ml triflouroacetic acid. To the stirring solution was added 8.77 ml (54.9 mmol) of triethylsilane while cooling to prevent exotherm, and the reaction stirred 16 hours at room temperature. The reaction was then poured into ice water, stirred and the beige solid filtered, washed with water and hexane, and dried to give 5-(2-chloroethyl)oxindole, m.p. 168°-170° C., 3.0 grams (64%).

후처리

  1. customTo a 100 ml round-bottomed flask equipped with condenser and nitrogen inlet
  2. temperaturewhile cooling
  3. stirringstirred
  4. filtrationthe beige solid filtered
  5. washwashed with water and hexane
  6. customdried

출처 및 근거

ORD 기록
ord-2379691d62994198bcc87b419281c897
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06127373

반응 노트

불러오는 중…