Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 1-(Tert-butyldiphenylsilyloxymethyl)-2,6-dimethyl-3-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| 반응물 | (2,6-Dimethyl-3-nitrophenyl)methanol | HCID 10487641 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(Tert-butyldiphenylsilyloxymethyl)-2,6-dimethyl-3-nitrobenzene | HCID 10764557 | 109.5% |
반응 단계
To a solution of tert-butyldiphenylsilyl chloride (30.7 g) in N,N-dimethylformamide (90 ml) were added 2,6-dimethyl-3-nitrobenzyl alcohol (18.4 g) and imidazole (8.99 g) under ice-cooling, and the mixture was stirred for 15 minutes at the same temperature and for 3 hours at ambient temperature. Water was added thereto, and the mixture was extracted with ethyl acetate. The extract was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo to give 1-(tert-butyldiphenylsilyloxymethyl)-2,6-dimethyl-3-nitrobenzene (46.67 g) as pale yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06127389 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-53e15f33c82140ac8dba9d8e0aa992cf |
| 출처 메모 | uspto-grants-2000_10 |