Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (E)-3-(6-Acetamidopyridin-3-YL)acrylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Acrylic Acid | HCID 6581 | — |
| 반응물 | Tributylamine | HCID 7622 | — |
| 반응물 | 2-Acetamido-5-bromopyridine | HCID 293097 | — |
| 촉매 | Triphenylphosphine | HCID 11776 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | (E)-3-(6-Acetamidopyridin-3-YL)acrylic acid | HCID 10703461 | 75.2% |
반응 단계
To a mixture of 2-acetamido-5-bromopyridine (240 mg), tri-n-butylamine (456 mg), palladium(II) acetate (0.13 mg) and triphenylphosphine (1.5 mg) in xylene (0.48 ml) was dropwise added acrylic acid (97 mg) at 150° C., and the mixture was stirred for 7 hours at the same temperature. After cooling the mixture, water was added thereto, and the mixture was adjusted to pH4 with hydrochloric acid. The precipitate was collected by filtration, washed with xylene and water, and dried to give (E)-3-(6-acetamidopyridin-3-yl)acrylic acid (173 mg) as yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06127389 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-6c49bb09f0434218a708cc369e424a1f |
| 출처 메모 | uspto-grants-2000_10 |