Sulfuryl chloride → 4-Acryloyl-2-chloro-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine

반응식

[C:1]([N:5]1[CH2:11][C:10]2[CH:12]=[C:13]([O:16][CH3:17])[CH:14]=[CH:15][C:9]=2[S:8][CH2:7][CH2:6]1)(=[O:4])[CH:2]=[CH2:3].S(Cl)([Cl:21])(=O)=O>>[C:1]([N:5]1[CH2:11][C:10]2[CH:12]=[C:13]([O:16][CH3:17])[CH:14]=[CH:15][C:9]=2[S:8][CH:7]([Cl:21])[CH2:6]1)(=[O:4])[CH:2]=[CH2:3]

참가 물질

반응물 2

HCID 24648Sulfuryl chloride

HCID 113910241-(7-Methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)prop-2-en-1-one

생성물 1

HCID 152916474-Acryloyl-2-chloro-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine수율 52.7%

실험 절차

4-Acryloyl-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (4.0 g) and sulfuryl chloride (2.3 g) were reacted in the same manner as in Experimental Example 7 to give 4-acryloyl-2-chloro-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (2.4 g).

출처 및 근거

ORD 기록: ord-dd3db43f1983436cb60adb96c8a9a256
출처 데이터셋: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05416066

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