Geraniol → 4-Acryloyl-2-geranyloxy-2,3,4,5-tetrahydro-1,4-benzothiazepine
반응식
[C:1]([N:5]1[CH2:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[S:8][CH:7](Cl)[CH2:6]1)(=[O:4])[CH:2]=[CH2:3].[CH3:17][C:18](=[CH:20][CH2:21][CH2:22]/[C:23](=[CH:25]/[CH2:26][OH:27])/[CH3:24])[CH3:19]>[Cl-].[Zn+2].[Cl-]>[C:1]([N:5]1[CH2:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[S:8][CH:7]([O:27][CH2:26]/[CH:25]=[C:23](/[CH2:22][CH2:21][CH:20]=[C:18]([CH3:19])[CH3:17])\[CH3:24])[CH2:6]1)(=[O:4])[CH:2]=[CH2:3]참가 물질
4
실험 절차
The above-mentioned 4-acryloyl-2-chloro-2,3,4,5-tetrahydro-1,4-benzothiazepine (1.0 g), geraniol (0.9 g) and zinc chloride (0.8 g) were reacted in the same manner as in Experimental Example 9 to give 4-acryloyl-2-geranyloxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (1.0 g).