Ammonia → 4-(Bromoheptyl)-2,6-dimethyl pyridine
반응식
[N:1]1[C:6]([CH3:7])=[CH:5][C:4]([CH3:8])=[CH:3][C:2]=1[CH3:9].[Br:10][CH:11](Br)[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].N>O1CCCC1>[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:8][C:4]1[CH:5]=[C:6]([CH3:7])[N:1]=[C:2]([CH3:9])[CH:3]=1참가 물질
5
반응 조건
- 온도
- -40 °C
실험 절차
Sodium amide was formed from sodium (1.0 g, 43.5 mmol) in liquid ammonia (100 ml) according to Example 1. Collidine (1) (5.0 g, 41.3 mmol) dissolved in tetrahydrofuran (5 ml) was added dropwise and after 45 min a well-cooled solution of dibromohexane (51.2 g, 210 mmol) in THF (100 ml) was added quickly. The reaction mixture was stirred for 1 h at -40° C. and then left stirring overnight during which times ammonia evaporated.
후처리
- additionwas added quickly
- waitleft
- customevaporated
출처 및 근거
- ORD 기록
- ord-2f6847b9949c45f795afa97ecc22a46c
- 출처 데이터셋
- uspto-grants-2000_10
- 특허 번호
- US06127529
반응 노트
불러오는 중…