Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → Ethyl 2,2-difluoro-3-hydroxypropanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Ethyl bromodifluoroacetate | HCID 69585 | — |
| 촉매 | Zinc | HCID 23994 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Ethyl 2,2-difluoro-3-hydroxypropanoate | HCID 2758828 | — |
반응 단계
A mixture of paraformaldehyde (4.5 g, 50 mmol), ethyl difluorobromoacetate (10.2 g, 50 mmol) and activated zinc dust (3.3 g, 40 mmol) in anhydrous tetrahydrofuran was heated under reflux for 0.5 h. Then the mixture was treated with a saturated aqueous solution of ammonium chloride and extracted with diethyl ether. After usual work-up the desired compound ethyl 2,2-difluoro-3-hydroxypropionate was obtained by flash chromatography on silica gel (ethyl acetate:hexane; 25:75) (4.1 g, 53%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05416076 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-07cd20d9a5744d628778aeaa05aa92ac |
| 출처 메모 | uspto-grants-1995_05 |