Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-Bromo-6-hydroxy-2-methylbenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Ethyl 3-bromo-6-hydroxy-2-methylbenzoate | HCID 23293235 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Bromo-6-hydroxy-2-methylbenzoic acid | HCID 11053451 | — |
반응 단계
A mixture of 1A (20.2 g, 0.078 mol), ethanol (150 ml) and an aqueous sodium hydroxide (12 g, 0.3 mol in 100 ml water) is heated under reflux with stirring for 16 hours. The reaction mixture is cooled to room temperature, diluted with water (600 ml) and acidified with concentrated hydrochloric acid. The precipitate is collected and washed with water yielding 18.45 g (100%) white crystals with a melting point of 163-165° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06127570 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-1ca1a3967616418894d2d29c8c92c8a9 |
| 출처 메모 | uspto-grants-2000_10 |