Methanol → (3-Bromo-6-hydroxy-2-methylphenyl)(2,3,4-trimethoxy-6-methylphenyl)methanone

HRID 365958노트

반응식

HRID 365958 반응식
C([O:4][C:5]1[CH:25]=[CH:24][C:23]([Br:26])=[C:22]([CH3:27])[C:6]=1[C:7]([C:9]1[C:14]([CH3:15])=[CH:13][C:12]([O:16][CH3:17])=[C:11]([O:18][CH3:19])[C:10]=1[O:20][CH3:21])=[O:8])(=O)C.C(=O)([O-])[O-].[K+].[K+].CO>O>[Br:26][C:23]1[CH:24]=[CH:25][C:5]([OH:4])=[C:6]([C:22]=1[CH3:27])[C:7]([C:9]1[C:14]([CH3:15])=[CH:13][C:12]([O:16][CH3:17])=[C:11]([O:18][CH3:19])[C:10]=1[O:20][CH3:21])=[O:8]

참가 물질

5

반응물 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 109062512-Acetoxy-5-bromo-6,6'-dimethyl-2', 3', 4'-trimethoxy-benzophenone

생성물 1

HCID 10938097(3-Bromo-6-hydroxy-2-methylphenyl)(2,3,4-trimethoxy-6-methylphenyl)methanone

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of 1D (0.7 g, 1.6 mmol), potassium carbonate (0.7 g), methanol (10 ml) and water (5 ml) is stirred at room temperature for 20 hours. The reaction mixture is poured into water and extracted with diisopropylether. The organic phase is separated and concentrated. The pure product is obtained as a yellow solid, 0.48 g (75.9%), mp. 119-120° C.

후처리

  1. extractionextracted with diisopropylether
  2. customThe organic phase is separated
  3. concentrationconcentrated
  4. customThe pure product is obtained as a yellow solid, 0.48 g (75.9%), mp. 119-120° C.

출처 및 근거

ORD 기록
ord-ee76843728674c7b8b3741362ba4a957
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06127570

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