Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 2-Pivaloyloxy-5-bromo-6-methylbenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Pivaloyl chloride | HCID 62493 | — |
| 반응물 | 3-Bromo-6-hydroxy-2-methylbenzoic acid | HCID 11053451 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-Pivaloyloxy-5-bromo-6-methylbenzoic acid | HCID 23293234 | — |
반응 단계
A mixture of 1B (6.45 g, 28 mmol), pivaloylchloride (3.62 g, 30 mmol), tetrahydrofuran (60 ml) and pyridine (2.45 ml) is stirred at room temperature for 16 hours. The reaction mixture is diluted with water and ethyl acetate. The organic phase is washed with water twice. The organic phase is concentrated in vacuo and the residue is re-crystallized from petrol ethers/diisopropylether (9:1 v/v) yielding the pure product as a white crystals, 6.3 g, (71.6%), mp. 144-145° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06127570 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-32e49ff7cf8e465b838d4cd342ec1d7d |
| 출처 메모 | uspto-grants-2000_10 |