Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chlorodifluoromethane → 4-difluoromethoxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chlorodifluoromethane | HCID 6372 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Di-tert-butyl 4-hydroxypyrazolidine-1,2-dicarboxylate | HCID 10334299 | — |
| 촉매 | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-difluoromethoxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester | HCID 53779472 | 33.3% |
반응 단계
0.2 g of tetrabutylammonium fluoride and 5.6 g of potassium hydroxide powder are added to a solution of 6.9 g of 4-hydroxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester in 60 ml of tetrahydrofuran. At a maximum of 45° C., 8.0 g of chlorodifluoromethane are introduced. The reaction solution is then filtered, concentrated and purified by means of column chromatography to yield 2.7 g of the desired product, 4-difluoromethoxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester, in the form of a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05416065 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-ab3109325d83479eba6f59e9863eaba5 |
| 출처 메모 | uspto-grants-1995_05 |