5,8,9,10-tetrahydro-4H-acephenanthrylen-7-one → 7-Hydroxy-7-methyl-7,8,9,10-tetrahydroacephenanthrene

HRID 36629

반응식

HRID 36629 반응식
[CH3:1][Mg]I.[CH:4]1[C:18]2=[C:19]3[C:10](=[CH:11][C:12]4[C:13](=[O:20])[CH2:14][CH2:15][CH2:16][C:17]=42)[CH2:9][CH2:8][C:7]3=[CH:6][CH:5]=1>CCOCC>[OH:20][C:13]1([CH3:1])[CH2:14][CH2:15][CH2:16][C:17]2[C:18]3=[C:19]4[C:10]([CH2:9][CH2:8][C:7]4=[CH:6][CH:5]=[CH:4]3)=[CH:11][C:12]1=2

참가 물질

4

반응물 2

HCID 3439545,8,9,10-tetrahydro-4H-acephenanthrylen-7-oneHCID 178418373HCID 178418373, 화합물

생성물 1

HCID 199374177-Hydroxy-7-methyl-7,8,9,10-tetrahydroacephenanthrene수율 62%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

Methylmagnesium iodide in ether (1.51 mL of 3.0M) was added slowly to an ice bath cooled suspension of 7,8,9,10-tetrahydroacephenanthren-7-one (Scott, L. T.; Reinhardt, G.; Roelofs, N. H. J. Org. Chem. 1985, 50, 5886) (0.25 g, 1.13 mmol) in ether (10 mL). The bath was removed and the reaction mixture was allowed to warm to room temperature over 1.5 h. The reaction mixture was again cooled to 0° C. and quenched with saturated aqueous ammonium chloride solution. The reaction mixture was concentrated under reduced pressure. The resulting solid was purified via flash chromotography to give 0.17 g (62%) of a crystalline solid: MS (CI) m/e (%) 239 (M+H+, 100); 1H NMR (CDCl3, 300 MHz) δ 7.64 (d, 1H, J=8.0 Hz), 7.57 (s, 1H), 7.46 (t, 1H, J=8.4 Hz), 7.28 (d, 1H, J=6.6 Hz), 3.37 (s, 4H), 3.08 (m, 2H), 2.02 (m, 4H), 1.80 (s, 1H), 1.63 (s, 3H).

후처리

  1. temperaturecooled
  2. customThe bath was removed
  3. temperatureThe reaction mixture was again cooled to 0° C.
  4. customquenched with saturated aqueous ammonium chloride solution
  5. concentrationThe reaction mixture was concentrated under reduced pressure
  6. customThe resulting solid was purified via flash chromotography

출처 및 근거

ORD 기록
ord-19b432aa4b7b4791a88a1dfa8ac4dd9e
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416089

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