Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-(4-Fluorophenyl)-1, 4-dihydro-indeno [1, 2-c] pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Fluorophenylhydrazine hydrochloride | HCID 69981 | — |
| 반응물 | 1H-Inden-1-one, 2,3-dihydro-2-(hydroxymethylene)- | HCID 3764882 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-(4-Fluorophenyl)-1, 4-dihydro-indeno [1, 2-c] pyrazole | HCID 12291066 | — |
반응 단계
2-Hydroxymethylene indan-1-one, (Example 1(ii) (a) (4.004 g; 250 mmol), p-fluorophenyl hydrazine hydrochloride (Aldrich) (4.106 g; 25.25 mmol) 10M hydrochloric acid (1 cm3) and ethanol (30 cm3), were heated under reflux for 19 hours. After cooling, the solvent was evaporated under reduced pressure, then taken up in dichloromethane and washed with 2M NaOH. The organic layer was separated, dried (Na2SO4), filtered and concentrated in vacuo. Purification by Kugelrohr distillation (140° C.; 0.01 mmHg) afforded a yellow solid, m.p. 104-105° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06130228 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-538bde8ff3034153b72fd8cf2836b91c |
| 출처 메모 | uspto-grants-2000_10 |