Acetic Acid → HCID 22448959, 화합물

HRID 366456노트

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HRID 366456 반응식
[OH:1][C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:11](=[O:13])[NH:12][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:14](O)(=[O:16])[CH3:15]>N1C=CC=CC=1>[C:14]([O:1][C:2]1[C:7]2[CH2:8][CH2:9][CH2:10][C:11](=[O:13])[NH:12][C:6]=2[CH:5]=[CH:4][CH:3]=1)(=[O:16])[CH3:15]

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 99422906-Hydroxy-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

생성물 1

HCID 22448959HCID 22448959, 화합물수율 87%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A suspension of 1,3,4,5-tetrahydro-6-hydroxy-2H-1-benzazepin-2-one (500 mg, 2.82 mmol) in 2.5 mL each of pyridine and acetic acid was stirred at room temperature. Excess reagents were removed under reduced pressure and the residue was triturated with CH2Cl2 to give 540 mg (87%) of 1,3,4,5-tetrahydro-6-acetoxy-2H-1-benzazepin-2-one; MS 219.

후처리

  1. customExcess reagents were removed under reduced pressure
  2. customthe residue was triturated with CH2Cl2

출처 및 근거

ORD 기록
ord-70c2dc89be7249f8a3520f32da86a2e0
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06130217

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