Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromoaniline → 1-(t-Butyldimethylsiloxy)-4-(3-amino-phenyl)-3-butyne
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromoaniline | HCID 11562 | — |
| 반응물 | (But-3-yn-1-yloxy)(tert-butyl)dimethylsilane | HCID 4304567 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Butylamine | HCID 8007 | — |
| 생성물 | 1-(t-Butyldimethylsiloxy)-4-(3-amino-phenyl)-3-butyne | HCID 22225739 | — |
반응 단계
A mixture of 1-(t-butyldimethylsilyloxy)-3-butyne (10 mmol) and m-bromoaniline (10 mmol) in n-butylamine (50 mL) under a nitrogen atmosphere is treated with tetrakis(triphenylphosphine)palladium (0) (0.17 g) and then heated to reflux for 18 hr. After removing the solvent in vacuo, the residue is dissolved in CH2Cl2 and washed with saturated NaHCO3. The combined organic solution is dried over magnesium sulfate, filtered and evaporated to give the above described silyl protected adduct.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06130234 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-2bffa424f5384ed486a6d8f0e064a4a9 |
| 출처 메모 | uspto-grants-2000_10 |