tert.-Butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3yl)carbamate → rac-tert-butyl N-[(3R,4R)-4-methoxypyrrolidin-3-yl]carbamate

HRID 36654노트

반응식

HRID 36654 반응식
C([N:8]1[CH2:12][C@@H:11]([O:13][CH3:14])[C@H:10]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH3:14][O:13][C@@H:11]1[CH2:12][NH:8][CH2:9][C@H:10]1[NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21]

참가 물질

4

반응물 1

HCID 15069969tert.-Butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3yl)carbamate

생성물 1

HCID 15069971rac-tert-butyl N-[(3R,4R)-4-methoxypyrrolidin-3-yl]carbamate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

6.7 g (22 mmol) of tert.-butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3-yl)carbamate are hydrogenated in 150 ml of methanol on 2 g of palladium-on-active charcoal (10% of Pd) under 100 bar at 100° C. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

후처리

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-94462c4fdb6a43548a178c056ea9d5a2
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416096

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