6-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine → Octahydropyrrolo[3,4-b][1,4]oxazine

HRID 36659노트

반응식

HRID 36659 반응식
C([N:8]1[CH2:16][CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][O:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH:15]12[CH2:16][NH:8][CH2:9][CH:10]1[NH:11][CH2:12][CH2:13][O:14]2

참가 물질

4

반응물 1

HCID 150699806-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

생성물 1

HCID 15069981Octahydropyrrolo[3,4-b][1,4]oxazine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

7.2 g (33 mmol) of 8-benzyl-2-oxa-5,8-diazabicyclo-[4.3.0]nonane are hydrogenated in 400 ml of methanol with 2.5 g of palladium-on-active charcoal (10% of Pd) under 50 bar at 100° C. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

후처리

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-71769ecc5c7245ceb8fe74475d841013
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416096

반응 노트

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