HCID 178418361, 화합물 → Tetrahydro-6-(phenylmethyl)-1H-pyrrolo(3,4-b)pyridine-5,7(2H,6H)-dione

HRID 36670

반응식

HRID 36670 반응식
[CH2:1]([N:8]=[C:9]([C:11]1[C:16]([C:17]([OH:19])=O)=[CH:15][CH:14]=[CH:13][N:12]=1)[OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>COCCO.[Ru]>[CH2:1]([N:8]1[C:17](=[O:19])[CH:16]2[CH:11]([NH:12][CH2:13][CH2:14][CH2:15]2)[C:9]1=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 178418361HCID 178418361, 화합물HCID 178524453HCID 178524453, 화합물

생성물 1

HCID 9899604Tetrahydro-6-(phenylmethyl)-1H-pyrrolo(3,4-b)pyridine-5,7(2H,6H)-dione수율 90.1%

시약·촉매·용매 2

HCID 23950Ruthenium촉매HCID 80192-Methoxyethanol용매

실험 절차

47.6 g (0.2 mol) of pyridine-2,3-dicarboxylic acid N-benzylimide (British Patent 1,086,637; Chem. Abstr. 68, 95695w) are hydrogenated in 400 ml of glycol monomethyl ether over 15 g of ruthenium-on-active charcoal (5% strength) at 90° C. under 100 bar until the calculated amount of hydrogen has been taken up. The catalyst is then filtered off and the filtrate is concentrated on a rotary evaporator. 44 g of an oily crude product are obtained.

후처리

  1. filtrationThe catalyst is then filtered off
  2. concentrationthe filtrate is concentrated on a rotary evaporator

출처 및 근거

ORD 기록
ord-bf9368f3c5cc400ebb2cbd0b81b4c1fc
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416096

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