Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate → (S)-N-Boc-2-ethynylpyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate | HCID 2734674 | — |
| 반응물 | Diazomethyl-phosphonic-acid-diethylester | HCID 10943016 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | (S)-N-Boc-2-ethynylpyrrolidine | HCID 11030701 | — |
반응 단계
(S)-N-Boc-2-Ethynyl-pyrrolidine was prepared according to Method X above by the treatment of (S)-N-Boc-2-formyl-pyrrolidine (470 mg, 2.36 mmol) (Example 87A above) with potassium tert-butoxide (340 mg, 3.07 mmol) and diazomethyl-phosphonic-acid-diethylester (550 mg, 3.07 mmol) (also prepared according to Method X). The product was obtained after silica gel coloumn chromatography with 10% Et2O in hexanes. (Yield 200 mg, 43%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06130239 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-034ed20d26b14257b11ece4674ce6a50 |
| 출처 메모 | uspto-grants-2000_10 |