Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 366753생성일: 2026년 10월 26일
Ethyl 5-formyl-4-methyl-1h-pyrrole-3-carboxylate → (Z)-5-(5-Fluoro-4-iodo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester
https://huagongshe.com/reaction/366753
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl 5-formyl-4-methyl-1h-pyrrole-3-carboxylate | HCID 236067 | — |
| 반응물 | 5-Fluoro-4-iodoindolin-2-one | HCID 9795601 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 용매 | Piperidine | HCID 8082 | — |
| 생성물 | (Z)-5-(5-Fluoro-4-iodo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester | HCID 20667774 | — |
반응 단계
A suspension of 1,3-dihydro-5-fluoro-4-iodo-2H-indol-2-one (0.5 g, 1.8 mmol) (Example 2A) and 5-formyl-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (0.39 g, 2.17 mmol) (Example 116A above) in 1% piperidine in 2-propanol (6 mL) was heated at 80° C. for 3 h. The precipitate was collected and washed with water to give (Z)-5-(5-Fluoro-4-iodo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester. (Yield 0.67 g, 85%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06130239 |
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| 출처 데이터셋 | uspto-grants-2000_10 |
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| ORD ID | ord-c6ed23c93cfd469f8ec129e52c6f8016 |
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| 출처 메모 | uspto-grants-2000_10 |
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