Aniline → 1-Phenyl-2,5-dihydro-1H-pyrrole
반응식
[CH3:1]/[CH:2]=[CH:3]\[CH3:4].[NH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1(C)C=CC=CC=1>[C:6]1([N:5]2[CH2:4][CH:3]=[CH:2][CH2:1]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
To a solution of 60.0 g of the cis-2-butene derivative solution prepared in Example 1 and 250 g of toluene in a round flask reactor, 149.0 g (1.6 mol) of aniline was added dropwise with stirring for 30 min. at 50° C. After 2 hours of stirring, the crystallized solid was removed by filtration; 42.0 g of 35% HCl (aq) was added to the filtrate, and then excess benzylamine hydrochloride was removed by filtration or extraction. After the solvent was evaporated under reduced pressure, 52.2 g of 1-phenyl-3-pyrroline (yield 90.0%) was obtained.
후처리
- stirringAfter 2 hours of stirring
- customthe crystallized solid was removed by filtration
- addition42.0 g of 35% HCl (aq) was added to the filtrate
- customexcess benzylamine hydrochloride was removed by filtration or extraction
- customAfter the solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-b17f0fae9d664117a622fa1b257a71d3
- 출처 데이터셋
- uspto-grants-2000_10
- 특허 번호
- US06130338
반응 노트
불러오는 중…