Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → rac-(3R,4S)-1-benzylpyrrolidine-3,4-diol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methanesulfonic Acid | HCID 6395 | — |
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 반응물 | 1-Benzyl-2,5-dihydropyrrole | HCID 561506 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | rac-(3R,4S)-1-benzylpyrrolidine-3,4-diol | HCID 536645 | 85.9% |
반응 단계
To a solution of 15.9 g (0.1 mol) of 1-benzyl-3-pyrroline, 13.1 g (0.24 mol) of methanesulfonic acid (produced by Tokyo Chemical Industry Co., Ltd.), 15.0 g of water, and 60.0 g of acetone in a round flask reactor, 31.1 g (0.13 mol) of 70% m-CPBA (m-chloroperbenzoic acid produced by Tokyo Chemical Industry Co., Ltd.) was added with stirring and allowed to react for 10 hours at 40° C. without irradiation by lamps. After completion, acetone was evaporated under reduced pressure, neutralized by NaOH (aq), and extracted with toluene and water. And then after the solvent was evaporated under reduced pressure, 16.6 g of 1-benzyl-3,4-dihydroxypyrrolidine (yield 85.9%) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06130338 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-b9d8dbbae13c49c899e311dba0107054 |
| 출처 메모 | uspto-grants-2000_10 |