참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chloroacetaldehyde | HCID 33 | — |
| 반응물 | Deoxycytidine | HCID 13711 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | Ethenodeoxycytidine | HCID 107769 | — |
반응 단계
3,N4 -Ethenodeoxycytidine is synthesized according to the published procedure of Eberle et al. (Carcinogenesis 10:2751-2756, 1989). To 2'-deoxycytidine (8 mg, available from Sigma Chemical Company) in 0.4 mL of DMSO is added 0.04 mL of a 45% aqueous solution of chloroacetaldehyde and the reaction mixture is stirred for 1 hour at 70° C. The reaction mixture is then evaporated to dryness and the resulting residue purified by reverse-phase HPLC on a Nucleosil C18 column (Altech) to yield 3,N4 -ethenodeoxycytidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06132776 |
|---|
| 출처 데이터셋 | uspto-grants-2000_10 |
|---|
| ORD ID | ord-39f7cef867664f9b9434a2a4f9b1958b |
|---|
| 출처 메모 | uspto-grants-2000_10 |
|---|
