Methyl 3-bromo-2,4,5-trifluorobenzoate → Methyl 3-cyano-2,4,5-trifluoro-benzoate

HRID 367013노트

반응식

HRID 367013 반응식
Br[C:2]1[C:3]([F:14])=[C:4]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:5]([O:7][CH3:8])=[O:6].[Cu](C#N)[C:16]#[N:17]>CN(C)C=O>[C:16]([C:2]1[C:3]([F:14])=[C:4]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:5]([O:7][CH3:8])=[O:6])#[N:17]

참가 물질

4

반응물 2

HCID 18459836Methyl 3-bromo-2,4,5-trifluorobenzoateHCID 178418260HCID 178418260, 화합물

생성물 1

HCID 18417526Methyl 3-cyano-2,4,5-trifluoro-benzoate수율 66.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

269 g of methyl 3-bromo-2,4,5-trifluoro-benzoate and 108 g of copper cyanide are heated to reflux for 5 hours in 400 ml of dimethylformamide. All volatile constituents of the reaction mixture are then removed by distillation in vacuo. The distillate is then fractionated on a column. 133 g of methyl 3-cyano-2,4,5-trifluoro-benzoate of boiling point 88-89° C./0.01 mbar are obtained.

후처리

  1. customAll volatile constituents of the reaction mixture are then removed by distillation in vacuo

출처 및 근거

ORD 기록
ord-d705c77f39044b13bb017887475eccd2
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133260

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