Benzenamine, N-propyl- → 2-(N-phenyl-N-propylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one

HRID 367157

반응식

HRID 367157 반응식
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.S(Cl)(Cl)=O.[S-:15][C:16]#[N:17].[NH4+].[CH2:19]([NH:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:20][CH3:21]>CC(C)=O.CN(C=O)C>[C:23]1([N:22]([C:16]2[S:15][C:2]3[N:10]=[CH:9][CH:8]=[CH:7][C:3]=3[C:4](=[O:6])[N:17]=2)[CH2:19][CH2:20][CH3:21])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

참가 물질

7

반응물 4

HCID 12153Benzenamine, N-propyl-HCID 15666Ammonium thiocyanateHCID 24386Thionyl ChlorideHCID 762582-Chloronicotinic acid

생성물 1

HCID 232877162-(N-phenyl-N-propylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one수율 80.5%

시약·촉매·용매 2

HCID 180Acetone용매2회HCID 6228Dimethylformamide용매

실험 절차

The reaction procedure of Example 57 was followed except that 1.763 g (11.2 mmol) of 2-chloronicotinic acid, 15 ml of thionyl chloride, two droplets of DMF, 894 mg of ammonium thiocyanate, 15 ml of acetone, 1.59 g of N-propylaniline and 10 ml of acetone were used. The product was then recrystallized from ethanol to obtain 2.68 g of 2-(N-phenyl-N-propylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

후처리

  1. customThe reaction procedure of Example 57
  2. customThe product was then recrystallized from ethanol

출처 및 근거

ORD 기록
ord-c2e12f5aa62d4bf8bada23e707904610
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06133258

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