4-Chloro-4'-nitrobenzophenone → 4-Amino-4'-chlorobenzophenone

HRID 36719

반응식

HRID 36719 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1>C(O)C.[Pt]=O>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]([C:5]2[CH:17]=[CH:18][C:2]([Cl:1])=[CH:3][CH:4]=2)=[O:7])=[CH:9][CH:10]=1

참가 물질

4

반응물 1

HCID 3477714-Chloro-4'-nitrobenzophenone

생성물 1

HCID 35287064-Amino-4'-chlorobenzophenone수율 79.2%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

A suspension of 14.4g (54.8 mmol) of 4-chloro-4'-nitrobenzophenone and 66.9 mg, (0.5 mole %) of platinum oxide was stirred under hydrogen in 300 ml of ethanol for 2 hours The mixture was filtered, evaporated and purified by flash column chromatography (2-8% EtOAc/CH2C12) to obtain 10.05 g (72%) of the desired product as a yellow solid. 1H nmr (CDCl3) δ4.16 (2H, br s), 6.67 (2H, d), 7.43 (2H, d), 7.68 (2H, d), 7.69 (2H, d).

후처리

  1. filtrationwas filtered
  2. customevaporated
  3. custompurified by flash column chromatography (2-8% EtOAc/CH2C12)

출처 및 근거

ORD 기록
ord-53781cf8028d4ddc9316d7676db2b9e0
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416112

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