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Water → (-)-(1R)-1-(2,2-Dimethylbenzo[1,2-d]-1,3-dioxan-6-yl)2-[((2S)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)amino]-ethanol

HRID 367334
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인쇄 미리보기

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HRID 367334 반응식
[CH3:1][C:2]1([CH3:28])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C@@H:12]([OH:27])[C:13]([NH:15][C@H:16]3[CH2:25][CH2:24][C:23]4[C:18](=[CH:19][C:20]([OH:26])=[CH:21][CH:22]=4)[CH2:17]3)=O)=[CH:11][C:5]=2[CH2:4][O:3]1.N(CCO)(CCO)CCO.O>O1CCCC1>[CH3:1][C:2]1([CH3:28])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C@@H:12]([OH:27])[CH2:13][NH:15][C@H:16]3[CH2:25][CH2:24][C:23]4[C:18](=[CH:19][C:20]([OH:26])=[CH:21][CH:22]=4)[CH2:17]3)=[CH:11][C:5]=2[CH2:4][O:3]1
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참가 물질

5

반응물 3

HCID 962WaterHCID 7618TriethanolamineHCID 70136692(-)-(2R)-2-(2,2-dimethylbenzo[1,2-d]-1,3-dioxan-6-yl)-2-hydroxy-N-((2S)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide

생성물 1

HCID 70136859(-)-(1R)-1-(2,2-Dimethylbenzo[1,2-d]-1,3-dioxan-6-yl)2-[((2S)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)amino]-ethanol수율 84.7%

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매
3회

실험 절차

(-)-(2R)-2-(2,2-Dimethylbenzo[1,2-d]-1,3-dioxan-6-yl)-2-hydroxy-N-((2S)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide (686 mg) was dissolved in 50 ml of tetrahydrofuran, 3.58 ml of 2 M borane-dimethylsulfide complex in tetrahydrofuran was added, and the mixture was heated under reflux for 3 hours. Then, a solution of 1.34 g of triethanolamine in 5.0 ml of tetrahydrofuran was added, and the mixture was again heated under reflux for 15 hours. After cooling, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was washed with water and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the resulting residue was recrystallized from ethyl acetate to give 560 mg of (-)-(1R)-1-(2,2-dimethylbenzo[1,2-d]-1,3-dioxan-6-yl)-2-[((2S)-7-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)amino]ethanol having a melting point of 156 to 158° C.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. temperaturethe mixture was again heated
  4. temperatureunder reflux for 15 hours
  5. temperatureAfter cooling
  6. extractionthe mixture was extracted with ethyl acetate
  7. washThe extract was washed with water
  8. dry with materialdried over anhydrous magnesium sulfate
  9. customThe solvent was evaporated under reduced pressure
  10. customthe resulting residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-6aba3e79893d404e96b96985ccb37ecc
출처 데이터셋
uspto-grants-2000_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06133266

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