Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → 5-(Trifluoromethoxy)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Sodium Sulfate | HCID 24436 | — |
| 반응물 | 5-(trifluoromethoxy)-2,3-dihydro-1H-indole-2,3-dione | HCID 2732752 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-(Trifluoromethoxy)-1H-indole | HCID 17989050 | 23.3% |
반응 단계
Lithium aluminum hydride (10.4 mL, 1M in THF, 10.4 mmol) was added to a solution of 5-trifluoromethoxyisatin (0.8 g, 3.45 mmol) in THF at room temperature and the mixture was refluxed overnight. The reaction mixture was cooled, and Na2SO4 10H2O was added very carefully portionwise, followed by ethyl acetate. The reaction mixture was then filtered, and the filtrate was evaporated. The residual oil was purifed by column chromatography with ethyl acetate in hexanes (2:98) to yield 5-trifluoromethoxy-1H-indole (0.162 g, 23%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06133287 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-db4b385c5414493e9da7264059cc4606 |
| 출처 메모 | uspto-grants-2000_10 |