HCID 19937697, 화합물 → 2-Phenyl-1-tetralone

HRID 36740노트

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HRID 36740 반응식
[CH2:1]([Mg]Br)[CH3:2].Cl[CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1(C1C=CC=CC=1)[OH:16]>C1C=CC=CC=1>[C:2]1([CH:6]2[CH2:15][CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]2=[O:16])[CH:1]=[CH:8][CH:7]=[CH:6][CH:15]=1

참가 물질

4

반응물 2

HCID 19937697HCID 19937697, 화합물HCID 178418443HCID 178418443, 화합물

생성물 1

HCID 3483282-Phenyl-1-tetralone수율 187.8%

시약·촉매·용매 1

HCID 241Benzene용매

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온도
0 °C

실험 절차

Step C Add ethylmagnesium bromide (1.76 mL, 5.27 mmol, M in) dropwise to a 0° C. solution of 2-chloro-1-phenyl-1,2,3,4-tetrahydronaphth-1-ol (1.36 g, 5.27 mmol) in dry benzene (20 mL). Stir the solution at 0° C. for 30 min and heat to reflux for 5 hours. Cool the mixture to room temperature and quench with saturated NH4Cl (aqueous). Extract with ether, combine the ethereal extracts, wash with water and brine, dry over Na2SO4 and concentrate to provide 1.1 g (94%) of the title compound.

후처리

  1. temperatureheat
  2. temperatureto reflux for 5 hours
  3. temperatureCool the mixture to room temperature
  4. customquench with saturated NH4Cl (aqueous)
  5. extractionExtract with ether
  6. washwash with water and brine
  7. dry with materialdry over Na2SO4
  8. concentrationconcentrate

출처 및 근거

ORD 기록
ord-a1ff33aa23844205b97f4101a245f871
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416118

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