Benzenemethanamine, 3,4-dichloro- → 2-(Isoxazol-5-yl)-4-(3,4-dichlorobenzylamino)-5-methyl-thieno-[2,3-d]-pyrimidine

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH2:6].Cl[C:12]1[C:13]2[C:25]([CH3:26])=[CH:24][S:23][C:14]=2[N:15]=[C:16]([C:18]2[O:22][N:21]=[CH:20][CH:19]=2)[N:17]=1>>[O:22]1[C:18]([C:16]2[N:17]=[C:12]([NH:6][CH2:5][C:4]3[CH:7]=[CH:8][C:9]([Cl:10])=[C:2]([Cl:1])[CH:3]=3)[C:13]3[C:25]([CH3:26])=[CH:24][S:23][C:14]=3[N:15]=2)=[CH:19][CH:20]=[N:21]1

참가 물질

반응물 2

HCID 1608Benzenemethanamine, 3,4-dichloro-

HCID 184601204-Chloro-2-(isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

생성물 1

HCID 184598712-(Isoxazol-5-yl)-4-(3,4-dichlorobenzylamino)-5-methyl-thieno-[2,3-d]-pyrimidine

실험 절차

With the procedure of Example 1, the reaction of 3,4-dichlorobenzylamine with 4-chloro-2-(isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine yields 2-(isoxazol-5-yl)-4-(3,4-dichlorobenzylamino)-5-methyl-thieno-[2,3-d]-pyrimidine.

출처 및 근거

ORD 기록: ord-f5934e78ba424bb6932fe1d9f359ac8b
출처 데이터셋: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06133271

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