Ethyl 2-fluoro-5-nitrocarbanilate → Ethyl 5-amino-2-fluorocarbanilate

HRID 36798노트

반응식

HRID 36798 반응식
[F:1][C:2]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][C:3]=1[NH:4][C:5](=[O:9])[O:6][CH2:7][CH3:8].[H][H]>[C].[Pd].C(O)C>[NH2:14][C:11]1[CH:12]=[CH:13][C:2]([F:1])=[C:3]([CH:10]=1)[NH:4][C:5](=[O:9])[O:6][CH2:7][CH3:8]

참가 물질

5

반응물 2

HCID 2754990Ethyl 2-fluoro-5-nitrocarbanilateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 19937926Ethyl 5-amino-2-fluorocarbanilate수율 81%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

100.3 mg (10 wt %) of 5% palladium carbon (containing water) was added to a mixture of 1.00 g (4.39 mmol) of ethyl 2-fluoro-5-nitrocarbanilate and 20 ml of ethanol, and the resultant mixture was stirred until 309 ml of hydrogen was absorbed. The reaction mixture was filtered to remove the catalyst, and the solvent was then distilled off under a reduced pressure. Thus, 700 mg of the objective product (yield: 81%) was obtained in the form of light brown crystals.

후처리

  1. customwas absorbed
  2. filtrationThe reaction mixture was filtered
  3. customto remove the catalyst
  4. distillationthe solvent was then distilled off under a reduced pressure

출처 및 근거

ORD 기록
ord-b0f5a2a0fb2a496cacb3d62cd4530814
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416236

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