Chlorine → Ethyl 4-chloro-5-ethylsulfonylamino-2-fluorocarbanilate

HRID 36800노트

반응식

HRID 36800 반응식
[CH2:1]([S:3]([NH:6][C:7]1[CH:8]=[CH:9][C:10]([F:19])=[C:11]([CH:18]=1)[NH:12][C:13](=[O:17])[O:14][CH2:15][CH3:16])(=[O:5])=[O:4])[CH3:2].[Cl:20]Cl>O1CCOCC1.O>[Cl:20][C:8]1[C:7]([NH:6][S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])=[CH:18][C:11]([NH:12][C:13](=[O:17])[O:14][CH2:15][CH3:16])=[C:10]([F:19])[CH:9]=1

참가 물질

5

반응물 2

HCID 24526ChlorineHCID 10891582Carbamic acid, [5-[(ethylsulfonyl)amino]-2-fluorophenyl]-, ethyl ester

생성물 1

HCID 10903456Ethyl 4-chloro-5-ethylsulfonylamino-2-fluorocarbanilate수율 86%

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

0.50 g (1.72 mmol) of ethyl 5-ethylsulfonylamino-2-fluorocarbanilate was dissolved in a mixture of 5 ml of dioxane and 1 ml of water, and chlorine gas was added to the resultant solution at a temperature of not higher than 25° C. until the starting material disappeared. After the reaction was completed, the surplus chlorine gas was removed by blowing nitrogen gas thereinto, and water was added. The precipitates crystals were filtered out and dried to obtain 0.48 g of the objective product (yield: 86%) in the form of light brown crystals.

후처리

  1. customthe surplus chlorine gas was removed
  2. additionwater was added
  3. filtrationThe precipitates crystals were filtered out
  4. customdried

출처 및 근거

ORD 기록
ord-37eb7b14a6974094b8b91fc26352c817
출처 데이터셋
uspto-grants-1995_05
특허 번호
US05416236

반응 노트

불러오는 중…